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  1. 1. Factors influencing the evolution of HIV-1

    Författare :Markus Birk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; antiretroviral treatment; evolution; gag; pol; env;

    Sammanfattning : Due to the high replication rate and the low fidelity of the viral reverse transcriptase (RT), various mutations are introduced continuously into the gene pool of HIV-1. Together with recombination events this leads to the evolution of countless quasispecies. LÄS MER