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  1. 1. Mitotic aberrations in mammalian cells

    Författare :Anna Renglin Lindh; Thomas Helleday; Micheline Kirsch-Volders; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aneuploidy; mitotic aberrations; chemical effects; human cancer; DNA repair; Genetics; Genetik;

    Sammanfattning : Almost all cancer cells are aneuploid showing the wrong chromosome number and often with structural aberrations. The degree of aneuploidy correlates with an increase of the severity of the disease and tumour cells with chromosomal instability are more prone to acquire resistance to chemotherapy than other cells. LÄS MER

  3. 2. Mitotic recombination in mammalian cells

    Författare :Catherine Arnaudeau; Harry Vrieling; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : Recombination is usually defined as the exchange of genetic material between two strands or regions of nucleic acids. This process occurs in all known organisms and is highly conserved, especially among higher eukaryotes. Various types of recombination, involving homologous or non-homologous nucleic acid sequences, are known to exist. LÄS MER

  4. 3. Messenger ribonucleoproteins from mammalian cells

    Författare :Bo Sundquist; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  5. 4. Replication Fork Stability in Mammalian Cells

    Författare :Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; Stockholms universitet; []
    Nyckelord :replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. LÄS MER

  7. 5. Replication fork stability in mammalian cells

    Författare :Ingegerd Elvers; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER