Sökning: "mammalian brain"

Visar resultat 1 - 5 av 125 avhandlingar innehållade orden mammalian brain.

1. 1. Mammalian brain acetylcholinesterase : a study of its solubilization, purification, molecular state and interactions with cholinergic ligands including an endogenous modulator

   Författare :Bertil Niklasson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity chromatography; caudate nucleus; acetylcholinesterase; tetracaine; décaméthonium; d-tubocurarine; edrophonium; fluoride ion; hysteric properties; endogenous ligands to AChE;

   Sammanfattning : Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. LÄS MER

3. 2. Regulation of site-selective A-to-I RNA editing : During mammalian brain development

   Författare :Helene Wahlstedt; Marie Öhman; Mary O'connell; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editering; ADAR; brain development; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

   Sammanfattning : Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in mammals that contributes to increase the protein diversity. Adenosine deaminases that act on RNA (ADARs) are the enzymes catalyzing RNA editing. ADARs are particularly active within the brain where they act on transcripts involved in neurotransmission. LÄS MER

4. 3. Effects of Mobile Phone Radiation upon the Mammalian Brain

   Författare :Henrietta Nittby; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mobile phone; electromagnetic radiation; Blood-brain barrier; brain; rat;

   Sammanfattning : oday about half of the world's population owns the microwave producing mobile phones. The blood-brain barrier (BBB) protects the mammalian brain from potentially harmful substances circulating in the blood. LÄS MER

5. 4. Mass Spectrometry-based Neuroproteomics : Deciphering the Human Brain Proteome

   Författare :Sravani Musunuri; Jonas Bergquist; Ganna Shevchenko; Jean-Charles Sanchez; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Brain; Proteomics; Mass spectrometry; Alzheimer s disease; Traumatic brain injury; Membrane proteins; Sample preparation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. LÄS MER

7. 5. Diversifying the transcriptome : Adenosine-to-inosine RNA editing in the mammalian brain

   Författare :Albin Widmark; Neus Visa; Joshua Rosenthal; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; microRNA; brain development; neuron; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Metazoan transcriptomes are extensively modified by adenosine-to-inosine (A-to-I) RNA editing, a process by which adenosines within double-stranded RNA are enzymatically deaminated to form inosines. Inosines has base-pairing characteristics similar to guanosine, meaning that A-to-I RNA editing results in functional rewriting of transcripts, affecting many biological processes. LÄS MER