Sökning: "malignancy"

Visar resultat 16 - 20 av 402 avhandlingar innehållade ordet malignancy.

  1. 16. Neutropenic fever during treatment of hematological malignancy : etiology and diagnostics

    Författare :Lennart Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Fever is the principal and sometimes the only manifestation of serious infection in the neutropenic patient because signs of inflammation may be minimal or absent in this group of patients. The aim of this thesis was to improve the clinical management of the febrile neutropenic patient. LÄS MER

  3. 17. Genetic studies of susceptibility to inflammation, autoimmunity, and hematological malignancy

    Författare :Bianca Tesi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system represents the body’s defense against infectious organisms. Inborn defects of the immune system, called primary immunodeficiencies (PIDs), are a heterogeneous group of Mendelian disorders. Clinically, PIDs can cause isolated to broad susceptibility to pathogens, severe hyperinflammation, autoimmunity, allergy, and cancer. LÄS MER

  4. 18. Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy

    Författare :Qing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic leukemia (CLL). However, a sub-group of patients develops resistance to ibrutinib therapy. LÄS MER

  5. 19. Biliary strictures in primary sclerosing cholangitis : aspects on inflammation and malignancy

    Författare :Erik von Seth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary sclerosing cholangitis (PSC) is a rare liver disease that is characterized by chronic inflammation of bile ducts with development of fibrosis and strictures. The pathogenic mechanisms involved in this disease are insufficiently understood. LÄS MER

  7. 20. Ovarian tumors. Prevalence, malignancy risk and significance of the Plasminogen activation system

    Författare :Christer Borgfeldt; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduktion; andrologi; gynekologi; sexuality; Obstetrik; Ovarian neoplasm; andrology; reproduction; epidemiology; ultrasonography; plasminogen activation; prognosis; gynaecology; Obstetrics; sexualitet;

    Sammanfattning : The aims were to assess the prevalence of ovarian tumors in fertile asymptomatic women and to evaluate the risk of ovarian cancer in women with a history of benign ovarian tumors and endometriosis. In order to search for biomarkers in ovarian tumors, the plasminogen activating (PA) system was studied. LÄS MER