Sökning: "magnus nisell"

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1. 1. Effects of nicotine on mesolimbocortical dopaminergic neurotransmission : a pharmacological study in the rat

   Författare :Magnus Nisell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :nicotine; dopamine; ventral tegmental area; accumbens; prefrontal cortex; c-fos; drug-dependence; sensitization; mecamylamine; D; receptors; SCH 23390;

   Sammanfattning : Tobacco-smoking represents a form of drug addiction to nicotine (NlC) and the reinforcing and dependence-producing properties of NIC depend largely on central dopamine (DA) neurons, located in the ventral tegmental area (VTA) and projecting mainly to the nucleus accumbens (NAc; mesolimbic DA system) and the medial prefrontal cortex (PFC; mesocortical DA system). Generally, the mesolimbic DA system plays a pivotal role in the reinforcing effects of natural rewards as well as of drugs of abuse. LÄS MER