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1. 1. Lead(II) as a Tool for Probing RNA Structure in vivo

   Författare :Magnus Lindell; Gerhart Wagner; Roland Hartmann; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; lead II cleavage; RNA structure; in vivo probing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : Chemical modification and limited enzymatic hydrolysis are powerful methods to obtain detailed information on the structure and dynamics of RNAs in solution. In the work presented here I have taken advantage of the properties of the divalent metal ion lead(II) to establish it as a new probe for investigating the structure of RNA in vivo. LÄS MER