Sökning: "macrolide resistance"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden macrolide resistance.

  1. 1. Microbial Responses to Antibiotics – Stability of Resistance and Extended Potential of Targeting the Folate Synthesis

    Författare :Maria Jönsson; Göte Swedberg; Steven Meshnick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; sulfonamide resistance; macrolide; commensal flora; substrate channeling; folate synthesis; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Resistance to antimicrobials is an increasing problem in the world of today, and develops faster than man can counter. It is therefore of importance to study metabolic pathways in order to develop new antibiotics, but also to understand how resistance spreads and stabilizes in microbial populations. LÄS MER

  3. 2. Macrolide Antibiotics in Bacterial Protein Synthesis

    Författare :Martin Lovmar; Måns Ehrenberg; Tanel Tenson; Peter B. Moore; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein synthesis; macrolides; resistance; initiation of translation; non-competitive inhibitors; kinetics; translation accuracy; proof-reading; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Macrolides are a large group of clinically relevant antibiotics that inhibit protein synthesis by binding to the large ribosomal subunit in the peptide exit tunnel, close to the peptidyl transferase center (PTC). We have shown that the peptide length of the resulting peptidyl-tRNA drop-off products is proportional to the distance between the PTC and the respective macrolide in the tunnel. LÄS MER

  4. 3. Computational discovery of antibiotic resistance genes and their horizontal transfer

    Författare :David Lund; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; phylogenetic analysis; Antibiotic resistance; horizontal gene transfer; computational screening;

    Sammanfattning : Antibiotic resistance is increasing among clinical infections and represents one of the most serious threats to public health. Pathogens often become resistant by acquiring mobile antibiotic resistance genes (ARGs) via horizontal gene transfer (HGT). LÄS MER

  5. 4. Molecular detection and epidemiological studies of atypical bacteria causing respiratory tract infections

    Författare :Karolina Gullsby; Kåre Bondeson; Björn Olsen; Puolakkainen Mirja; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Mycoplasma pneumoniae; Bordetella pertussis; real-time PCR; P1 typing; MLVA; whole-genome sequencing; macrolide resistance; molecular diagnostics; molecular epidemiology;

    Sammanfattning : Respiratory infections are common causes of morbidity and mortality. Chlamydia pneumoniae, Mycoplasma pneumoniae and Bordetella pertussis cause respiratory infection, often with similar symptoms. Molecular diagnostic methods are preferred since these bacteria are difficult to culture. LÄS MER

  7. 5. Group A Streptococci; Epidemiology and Genetics of Antibiotic Resistance

    Författare :Aftab Jasir; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; typing; epidemiology; M protein; emm gene; erythromycin; tetracycline; macrolides; streptococci; antibiotics; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology;

    Sammanfattning : Group A streptococci (GAS) cause throat and skin infections, severe invasive diseases as well as the non-suppurative complications acute rheumatic fever and glomerulonephritis. GAS have retained susceptibility to betalactam drugs, but resistance to alternative antibiotics is of concern. LÄS MER