Sökning: "mTORC1"

Visar resultat 6 - 10 av 27 avhandlingar innehållade ordet mTORC1.

  1. 6. Molecular mechanisms of ovarian follicular development and early embryogenesis

    Författare :Nagaraju Gorre; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicles; Embryogenesis; PI3K-mTORC1 signaling;

    Sammanfattning : In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and fertilizable ova for the entire reproductive life. In addition, the duration of fertility of a female is determined by the initial size of her pool of primordial follicles and by the rate of its activation and depletion. LÄS MER

  3. 7. Regulation of protein synthesis in human skeletal muscle : separate and combined effects of exercise and amino acids

    Författare :William Apró; Eva Blomstrand; Olav Rooyackers; Hans-Christer Holmberg; Michael Kjaer; Gymnastik- och idrottshögskolan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Medicin Teknik; Medicine Technology;

    Sammanfattning : Skeletal muscle is a highly plastic tissue which has the ability to adapt to various forms of external stimuli such as diverse modes of contractile activity. Thus, performance of endurance exercise over several of weeks results in increased oxidative capacity. LÄS MER

  4. 8. Exploring mTOR-dependent regulation of mRNA translation in cancer

    Författare :Hui Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation step during mRNA translation. Subsets of transcripts are discriminated by structural and/or sequence features, and encode proteins involved in different biological functions. LÄS MER

  5. 9. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)

    Författare :Meenu Rohini Rajan; Peter Strålfors; Mats Söderström; Olga Göransson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. LÄS MER

  7. 10. Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling

    Författare :Emanuela Santini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (SNc) and project to the striatum. LÄS MER