Sökning: "mTORC1"

Visar resultat 16 - 20 av 27 avhandlingar innehållade ordet mTORC1.

  1. 16. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

    Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER

  3. 17. On the therapeutic potential of cancer drugs for spinal cord injury

    Författare :Jacob Kjell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Spinal cord injury progresses in two stages. After the damage-causing physical event, comes an extended period when additional loss of cells and nerve fibers will occur and inflammatory and scar forming processes will come to prevail. LÄS MER

  4. 18. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Författare :Sofie Mohlin; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER

  5. 19. Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma

    Författare :Arash Hamidian; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2α; enChIP; ESRRA; mTORC2; IGF-II; Hypoxia; Cancer; PI3K; Transcription; Neuroblastoma;

    Sammanfattning : Neuroblastoma is a childhood tumor of the developing sympathetic nervous system (SNS) and is the most commonly diagnosed form of cancer in children before one year of age. Although survival curves have improved for these patients during the past decades, the conventional regimen of neuroblastoma treatment has clearly reached a plateau of efficiency with regard to increasing the survival rates of high-risk children. LÄS MER

  7. 20. Low Protein Diets and Their Effects on Brown Adipose Tissue

    Författare :Erik Lindsund; Jan Nedergaard; Eva Blomstrand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Obesity; Protein diets; Dietary protein; Brown adipose tissue; Brown fat; BAT; UCP10; Uncoupeling protein 1; molekylär biovetenskap; Molecular Bioscience; fysiologi; Physiology;

    Sammanfattning : Obesity is a rising health issue and has been linked with a relative decrease of dietary protein, which promotes higher food intake. Brown adipose tissue is a heat-producing, energy-wasting organ that has been shown to be enhanced by a low protein diet. However, the mechanism of how this occurs is largely unknown. LÄS MER