Sökning: "mTORC1"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet mTORC1.

  1. 1. Skeletal muscle fiber types in man : With special reference to anabolic signaling and mitochondrial bioenergetics

    Författare :Sebastian Edman; William Apro; Filip J Larsen; Abram Katz; Leigh Breen; Gymnastik- och idrottshögskolan; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mTORC1; THRIFTY; fiber type identification; muscle growth; aging; sarcopenia; mitochondrial function; oxphos; metabolism; Medicin Teknik; Medicine Technology;

    Sammanfattning : Human skeletal muscle consists of a mixture of slow-twitch (type I) and fast-twitch (type II) fibers. The type I fibers are endurance-oriented, with a metabolic system and infrastructure that supports aerobic metabolism. LÄS MER

  3. 2. Characterization of Amino Acid Transporters : Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38

    Författare :Sofie Victoria Hellsten; Robert Fredriksson; Gether Ulrik; Uppsala universitet; []
    Nyckelord :Solute carriers; amino acid transporter; SLC38 family; SLC38A8; SNAT8; SLC38A10; SNAT10; SLC38A9; SNAT9; amino acid starvation; AAR; mTORC1; Neuroscience; Neurovetenskap;

    Sammanfattning : In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. LÄS MER

  4. 3. Signaling pathways in the development of female germ cells

    Författare :Deepak Adhikari; Kui Liu; Elisabet Stener-Victorin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicle; activation; mTORC₁; PI₃K; oocyte maturation; MPF; Cdk₁; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. LÄS MER

  5. 4. Characterization of Centrally Expressed Solute Carriers : Histological and Functional Studies with Transgenic Mice

    Författare :Sahar Roshanbin; Robert Fredriksson; David Engblom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLC; Solute carriers; Amino acid transporter; PAT; B0AT2; mTORC1; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The Solute Carrier (SLC) superfamily is the largest group of membrane-bound transporters, currently with 456 transporters in 52 families. Much remains unknown about the tissue distribution and function of many of these transporters. LÄS MER

  7. 5. Effects of exercise and amino acid intake on mechanisms regulating protein synthesis and breakdown in human muscle

    Författare :Marcus Moberg; Eva Blomstrand; Hans-Christer Holmberg; Jørgen Jensen; Gymnastik- och idrottshögskolan; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Resistance exercise; concurrent exericse; leucine; BCAA; mTORC1 signaling; protein synthesis; MuRF-1; PGC-1alpha; Medicin Teknik; Medicine Technology;

    Sammanfattning : Skeletal muscle adapts differently to specific modes of exercise, where resistance training results in muscle growth and endurance training induces mitochondrial biogenesis. These are results of molecular events that occur after each exercise session, increasing the expression of specific genes and the rate of both synthesis and breakdown of protein. LÄS MER