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  1. 1. Spatial control of mRNA stability in yeast

    Författare :Susanne Huch; Tracy Nissan; Anders Byström; Anders Virtanen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mRNA stability; P bodies; mRNA turnover; gene regulation; decapping factors; molekylärbiologi; Molecular Biology;

    Sammanfattning : The degradation of mRNA is an important modulator of gene expression and the ultimate fate of messenger mRNA. Important steps in the degradation of mRNA include initial shortening of its poly(A) tail followed by the subsequent removal of the m7G cap. These two processes are linked temporally as well as spatially. LÄS MER

  3. 2. Studies on mRNA turnover in bacteria

    Författare :Martin Persson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; aprE; GlpP; glpD; mRNA secondary structure; Bacillus subtilis; mRNA stability; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Genetic information, which is stored in DNA, is transferred to messenger RNA (mRNA) in a process called transcription. mRNAs are then translated by ribosomes into proteins which, with some important exceptions, catalyze chemical reactions in cells. Since cells must be able to adapt to changes in the environment, mRNAs must be unstable. LÄS MER

  4. 3. The Bacillus subtilis GlpP protein, antitermination and mRNA stability

    Författare :Elisabeth Glatz; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; leader sequence; glpD; GlpP; catabolite repression; mRNA stability; Bacillus subtilis; antiterminator protein; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Bacillus subtilis can grow on glycerol or glycerol-3-phosphate (G3P) as the sole carbon and energy source. The glpD gene encodes G3P dehydrogenase which is required for the catabolism of glycerol and G3P. LÄS MER

  5. 4. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

    Författare :Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. LÄS MER

  7. 5. Stability determinants and decay of Bacillus subtilis mRNAs

    Författare :Gustav Hambraeus; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; bacteriology; Microbiology; Bacillus subtilis; mRNA stability; degradation;

    Sammanfattning : Degradation of mRNA is a controlled process which is as important for gene regulation as the synthesis of mRNA. This thesis focuses on mechanisms of mRNA stability and degradation in Bacillus subtilis, the model of Gram-positive bacteria. LÄS MER