Sökning: "mRNA display"

Visar resultat 21 - 25 av 73 avhandlingar innehållade orden mRNA display.

  1. 21. Immune cells in pregnant uterine mucosa : functional properties, cellular composition and tissue organization

    Författare :Lucia Mincheva-Nilsson; Sten Hammarström; Rolf Kiessling; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunologically privileged site; TCR γδ cells; CD56 cells; large granular lymphocytes; immunosuppression; cytokine; interleukin; lymphoid cell cluster; intraepithelial lymphocytes; glandular epithelium; immuno electron microscopy; pregnancy; decidua; lactoferrin; lactoferrin receptor; colostrum;

    Sammanfattning : The pregnant uterus mucosa - decidua - is an "immunologically privileged" site. A semiallogeneic embryo is allowed to survive, develop, and grow while the same tissue implanted outside the uterus will be rejected. The decidua basalis, which participates in the placenta formation, is a tissue rich in lymphoid cells. LÄS MER

  3. 22. Genetic and epigenetic mechanisms in primary hyperparathyroidism

    Författare :Luqman Sulaiman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by abnormally excessive secretion of parathyroid hormone (PTH) and elevated serum calcium. PHPT patients can develop a wide range of complications affecting many body organs such as the skeleton, kidneys and heart. LÄS MER

  4. 23. Clinical and experimental studies on HFE and other genes involved in iron homeostasis

    Författare :Petra Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hereditary hemochromatosis; iron overload; HFE gene mutations; porphyria cutanea tarda; HFE gene; iron metabolism-related genes; iron homeostasis; liver; inflammation; and hepatocellular carcinoma;

    Sammanfattning : In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma were studied in experimental models. Hereditary hemochromatosis (HH) is a prevalent autosomal recessive iron overload disorder caused by increased intestinal absorption and deposition of iron in vital organs, leading to organ damage. LÄS MER

  5. 24. Evolution and Pharmacology of Receptors for Bradykinin and Neuropeptide Y in Vertebrates

    Författare :Torun Bromée; dan larhammar; Nina Mohell; Samuel Svensson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Pharmacology; Evolution; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled receptors (GPCRs). The GPCRs form the largest class of therapeutic targets and it is therefore of great interest to investigate the pharmacological properties, functions and evolution of these receptors. LÄS MER

  7. 25. The Role of Hexose Transport on Glycolytic Flux and Glucose Induced Responses in Saccharomyces cerevisiae

    Författare :Karin Elbing; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; glucose signaling; metabolic control; Snf1; glycolysis; Mig1; Hexose transport; Yeast; Saccharomyces cerevisiae;

    Sammanfattning : In the yeast Saccharomyces cerevisiae, glucose is primarily fermented rather than respired. Only in cultivation modes such as chemostats or fed-batches, where the external glucose is kept low, a fully respiratory catabolism is observed. LÄS MER