Sökning: "mPFC"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet mPFC.

  1. 11. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

    Författare :Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

    Sammanfattning : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. LÄS MER

  3. 12. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Författare :Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. LÄS MER

  4. 13. The neurocognitive basis of confabulatory introspection : Choice blindness and the brain

    Författare :Gabriel Vogel; Kognitionsvetenskap; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Confabulation; introspection; fMRI; sense of agency; decision; self-knowledge; metacognition; cognitive neuroscience;

    Sammanfattning : The goal of this thesis is to advance our understanding of introspection by studying when it fails, without us being aware of it. To do so, I have used the choice blindness paradigm. LÄS MER

  5. 14. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER

  7. 15. Essays on belief formation and pro-sociality

    Författare :Erik Mohlin; Handelshögskolan i Stockholm; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Sammanfattning : This thesis consists of four independent papers. The first two papers use experimental methods to study pro-social behaviors. The other two use theoretical methods to investigate questions about belief formation. The first paper “Communication: Content or Relationship?” investigates the effect on communication on generosity in a dictator game. LÄS MER