Sökning: "lysosomotropic agents"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden lysosomotropic agents.

  1. 1. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells

    Författare :Aida Paivandy; Gunnar Pejler; Magda Babina; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Granules; Apoptosis; Reactive oxygen species; ROS; Lysosomotropic agents; Mefloquine; Immunologi; Immunology; Biokemi; Biochemistry;

    Sammanfattning : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. LÄS MER

  3. 2. Virion- and VAP-receptor recognition in the human adenovirus type 2 system

    Författare :Eduardo Rodriguez; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; T7pol-M13; adenovirus fiber shaft fragment; receptor recirculation; lysosomotropic agents; Adenovirus; HeLa cells; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : This thesis is focused on the early steps of a complex virus-cell interaction. The human adenovirus type 2 (HAdV-2) infects permissive cells, by first recognizing a protein of the immunoglobulin superfamily that serves as the Coxsackie and adenovirus receptor (CAR). This attachment step is mediated by the adenovirus fiber protein. LÄS MER

  4. 3. Proton trapping in the cellular acidic vacuolar compartment : lysosomal mechanisms in apoptosis/necrosis and iron chelation

    Författare :Zhengquan Yu; Anders Isaksson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Under ischemic conditions, a number of cytotoxic metabolic products are formed. Reactive oxygen species are known to be important mediators of progressive ischemic cell injury, and the synergistic damage to cells caused by the combination of such oxygen species and redox-active iron is well appreciated. LÄS MER

  5. 4. Oxidized Lipids and Lysosomal Pathology in Atherogenesis

    Författare :Wei Li; Wendy Jessup; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Macrophages take up large amount of exogenous materials such as oxidatively modified low-density lipoproteins (oxLDL) and lysosomotropic agents. OxLDL is taken up into macrophage lysosomes through receptor-mediated endocytosis, but poorly degraded, resulting in foam cell formation. LÄS MER

  7. 5. Naturally derived cell-penetrating peptides and applications in gene regulation : A study on internalization mechanisms and endosomal escape

    Författare :Pontus Lundberg; Ülo Langel; Bernard Lebleu; Stockholms universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; endocytosis; gene regulation; Neurochemistry; Neurokemi;

    Sammanfattning : Cell-penetrating peptides are a class of peptides which have achieved a lot of recognition due to their vector abilities. Since their discovery over a decade ago, there has been an uncertainty concerning the mechanism by which they are internalized into the cells. LÄS MER