Sökning: "lysosomal pH"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden lysosomal pH.

1. 1. Degranulation in macrophages and other leukocytes: regulation by calcium, phosphoinositide 3-kinase, and protein kinase C

   Författare :Claes Nauclér; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lysosomal secretion; neutrophil; Clinical biology; proton pump; Klinisk biologi; exocytosis; lysosomal pH;

   Sammanfattning : Macrophages mediate innate immunity through release of cytokines, eicosanoids, reactive oxygen species as well as through phagocytosis and secretion of lysosomal enzymes. Regulation of lysosomal secretion in macrophages differs in several respects from release of specialized granules in other leukocytes. LÄS MER

3. 2. Impact of Lysosomal Function in Cancer and Apoptosis

   Författare :Cathrine Nilsson; Karin Öllinger; Emmanuelle Liaudet-Coopman; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

   Sammanfattning : Lysosomes, the recycling units of the cell, participate in the signaling pathway to apoptosis, which has stimulated the search for anti-cancer drugs targeting the lysosomal compartment. Lysosomes are, however, often altered in cancer cells. LÄS MER

4. 3. Proton trapping in the cellular acidic vacuolar compartment : lysosomal mechanisms in apoptosis/necrosis and iron chelation

   Författare :Zhengquan Yu; Anders Isaksson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Under ischemic conditions, a number of cytotoxic metabolic products are formed. Reactive oxygen species are known to be important mediators of progressive ischemic cell injury, and the synergistic damage to cells caused by the combination of such oxygen species and redox-active iron is well appreciated. LÄS MER

5. 4. Insulin-Producing Cells, Iron, Oxidative Stress, and Lysosomal Pathology

   Författare :Beata Teresa Olejnicka; Enrique Cadenas; Linköpings universitet; []
   Nyckelord :Insulin-producing cells; redox-active iron; oxidative stress; lysosomes; desfenioxamine; MEDICINE; MEDICIN;

   Sammanfattning : Accumulating evidence suggests that injnries caused by oxygen-derived radicals contribute to the destruction of pancreatic islet ß-cells in autoinnnune diabetes mellitus (diabetes type I, or IDDM). Oxidative stress may be caused by an enhanced production of oxygen-derived radicals, or by a decreased scavenging of such molecules. LÄS MER

7. 5. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

   Författare :Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

   Sammanfattning : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. LÄS MER