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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Theoretical Modeling and Near-Infrared Spectroscopy Monitoring of Vial Lyophilization

   Författare :Mikael Brülls; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; in-situ; simulation; monitoring; spectral peak area analysis; near-infrared spectroscopy; lyophilization; moisture; sublimation; vial; mathematical model;

   Sammanfattning : The research documented in this thesis was directed towards lyophilization of pharmaceuticals in vials (vial lyophilization) and it was focused on the design and control of this process. Theoretical modeling has considerable potential to guide experimental studies, thereby decreasing development time and improving the possibilities to achieve an optimal and robust process design. LÄS MER

3. 2. Enhancing the stability of probiotics: Freeze-drying and encapsulation

   Författare :Shuai Bai; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; freeze-drying; lyophilization; L.ruteri; Probiotics; Lyoprotectant; Structure; Encapsulating material; Pore size; Material thickness; SEM; Tomography; Storage stability; Amorphous sugars; Glass transition temperature; DSC;

   Sammanfattning : This research dives into the intricate world of freeze-drying, an essential process in pharmaceutical and probiotic industries, to better understand the factors affecting probiotic stability during storage. The process of freeze-drying and the composition of freeze-dried products significantly affect the stability of probiotics, yet factors such as the material’s encapsulation properties remain relatively unexplored, demanding further research. LÄS MER

4. 3. Live Biotherapeutics : importance of formulation and lyophilization parametersand an example of a clinical application

   Författare :Nisha Tyagi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of diseases. LÄS MER

5. 4. Advances in exosome-mediated immunotherapy and diagnostics

   Författare :Pia Larssen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Exosomes are small vesicles with immune-stimulatory capacity, which can activate T cell responses in a B cell dependent manner, and therefore may serve as immune therapeutic tools. Peptide-loaded dendritic cell (DC)-derived exosomes are proven safe in clinical trials, although with limited ability to induce cytotoxic T lymphocyte (CTL) responses or prolong patient survival. LÄS MER

7. 5. Amine Transaminases in Biocatalytic Amine Synthesis

   Författare :Henrik Land; Per Berglund; Helen C. Hailes; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amine Transaminase; Biocatalysis; Transamination; Reductive Amination; Enzyme; Enzyme Engineering; Equilibrium Displacement; Screening; Enzyme Stability; Bioteknologi; Biotechnology;

   Sammanfattning : The use of enzymes, nature´s own catalysts, both isolated or as whole cells to perform chemical transformations is called biocatalysis. As a complement to classical chemical catalysis, biocatalysis can be an environmentally friendly and more economical option in the production and synthesis of chemicals. LÄS MER