Sökning: "lymphokine activated killer"

Hittade 4 avhandlingar innehållade orden lymphokine activated killer.

  1. 1. Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1

    Författare :Anna Cartier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Us3; unique short 3; HSV; herpes simplex virus; NK; natural killer; LAK; lymphokine activated killer; MHC; major histocompatibility complex;

    Sammanfattning : The Herpes Simplex Virus 1 (HSV-1) US3 protein kinase is part of the anti-apoptotic arsenal that salvage HSV-1-infected cells from damage caused by different stimuli. The Us3 gene encodes a protein kinase that phosphorylates serine/threonine residues within a specific arginine-rich consensus sequence. LÄS MER

  3. 2. Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A

    Författare :Hans Belfrage; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; cytokine; tolerance; LAK; NK; serologi; CTL; Staphylococcal enterotoxin A; SEA; Interleukin-2; murine; deletion; anergy;

    Sammanfattning : Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. LÄS MER

  4. 3. Mechanisms of immune escape in EBV associated malignancies : Hodgkin's disease and Burkitt's lymphoma

    Författare :Teresa Frisan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epstein-Barr virus; tumor immune escape; antigen presentation; cytotoxic T lymphocytes;

    Sammanfattning : The work presented in this thesis is focused on the analysis of the mechanisms operating in the immune escape of two Epstein-Barr virus (EBV) associated tumors: Hodgkin's Disease (HD) and Burkitt's lymphoma (BL). EBV positive HD tumor cells express at least 3 viral proteins: the EBV nuclear antigen (EBNA)1, the latent membrane proteins (LMP)1 and LMP2A. LÄS MER

  5. 4. MHC class I restricted and antigen-specific TCRs against viral and tumor-associated antigens (TAAs) for future biological therapy

    Författare :Zhenjiang Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adoptive cellular immunotherapy (ACT) refers to the process of transferring immune cells (autologous or allogeneic) directly to the host as a treatment for cancer or infectious diseases. The effector cells could be antigen-specific, like T cells, or non-specific, such as NK cells or lymphokine-activated killer (LAK) cells. LÄS MER