Sökning: "lymphoid"

Visar resultat 1 - 5 av 275 avhandlingar innehållade ordet lymphoid.

  1. 1. Tertiary lymphoid structures in glioblastoma : Discovery, Characterization and Therapeutic Induction

    Författare :Alessandra Vaccaro; Anna Dimberg; Victor Engelhard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tertiary lymphoid structures; Glioma; Glioblastoma; Immunotherapy; Immunologi; Immunology; Oncology; Onkologi;

    Sammanfattning : Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The tumor microenvironment plays a major role in GBM progression through sustaining immunosuppression and poor lymphocytic infiltration. LÄS MER

  3. 2. Recurrent Genetic Mutations in Lymphoid Malignancies

    Författare :Emma Young; Richard Rosenquist; Larry Mansouri; Lesley Ann Sutton; Dimitar Efremov; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; mutations; CLL; stereotypy; subsets; PMBL; NFKBIE; EGR2; whole-genome sequencing; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

    Sammanfattning : In recent years, the genetic landscape of B-cell derived lymphoid malignancies, including chronic lymphocytic leukemia (CLL), has been rapidly unraveled, identifying recurrent genetic mutations with potential clinical impact. Interestingly, ~30% of all CLL patients can be assigned to more homogeneous subsets based on the expression of a similar or “stereotyped” B-cell receptor (BcR). LÄS MER

  4. 3. Prognostic markers and DNA methylation profiling in lymphoid malignancies

    Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

    Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER

  5. 4. Molecular mechanisms in lymphoid restriction : securing the B lineage fate

    Författare :Josefine Åhsberg; Mikael Sigvardsson; Jan-Ingvar Jönsson; Charles G. Mullighan; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. LÄS MER

  7. 5. Molecular genetics of lymphoid malignancies

    Författare :Mats Merup; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Advances in molecular genetics during the last decade has made it possible to identify genetic lesions in malignant cells that are specific for disease entities with a common clinical presentation and prognosis. In chronic lymphocytic leukemia (CLL) deletions in 13ql4 are the most frequently occurring abnormalities and deletions cluster around marker D13S319 suggesting that a tumor suppressor gene is located in this region. LÄS MER