Sökning: "lymphocyte binding"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden lymphocyte binding.

  1. 1. Human T-lymphocyte activation : interactions between lymphocytes and mitogenic or non-mitogenic lectins

    Författare :Marie-Louise Dillner-Centerlind; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of this investigation was to gain further insights in the mechanisms of T-lymphocyte activation by lectins. Interactions between the lectins and purified lymphocytes from human peripheral blood, were studied in the following respects: in vitro culture requirements for lectin induced DNA-synthesis, intercellular regulations of the mitogen response and binding of lectins to lymphocyte surface components. LÄS MER

  3. 2. Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro

    Författare :Håkan Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokine; adhesion molecule; endothelium; lymphocyte metabolism; interleukin 2 receptor; FK506; cyclosporin A; Mikrobiologi; bakteriologi; virologi; mykologi; Immunology; transplantation; serology; Microbiology; bacteriology; mycology; virology; Immunologi; serologi;

    Sammanfattning : In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. LÄS MER

  4. 3. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes

    Författare :Linda Zander; Göteborgs universitet; []
    Nyckelord :B lymphocyte; germinal centre; transformation; serum-free; MHC class II; bare lymphocyte syndrome; extracellular proteins; DNA repair; Polymerase ?;

    Sammanfattning : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. LÄS MER

  5. 4. Regulation of cytotoxic lymphocyte effector functions

    Författare :Giovanna Perinetti Casoni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studies of patients with inborn errors of immunity provide an important opportunity to understand the human immune system in a natural context. The articles in this thesis are a compilation of such investigations. LÄS MER

  7. 5. Human cytotoxic lymphocyte differentiation in health and disease

    Författare :Heinrich Schlums; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory cytokines and chemokines. NK cells and CD8+ T cells belong to different arms of the immune system, employing complementary strategies for target cell recognition. LÄS MER