Sökning: "lung model"

Visar resultat 1 - 5 av 332 avhandlingar innehållade orden lung model.

  1. 1. Intestinal effects of lung recruitment maneuvers

    Författare :Jonas Claesson; Ola Winsö; Stefan Lehtipalo; Conny Arnerlöv; Björn Biber; Göran Hedenstierna; Petter Aadahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute lung injury; oleic acid lung injury; ischemia; reperfusion injury; swine; mechanical ventilation; lung recruitment; splanchnic circulation; laser Doppler flowmetry; tissue oxygen tension; microdialysis; lactate; glycerol; Anaesthetics and intensive care; Anestesiologi och intensivvård; lungmedicin; Lung Medicine;

    Sammanfattning : Background and aims: Lung recruitment maneuvers (brief episodes of high airway pressure) are a modern treatment alternative to achieve open lung conditions under mechanical ventilation of patients with acute lung injury. It is well known that positive pressure ventilation with high airway pressures cause negative circulatory effects, and that the effects on regional vascular beds can be even more pronounced than the systemic effects. LÄS MER

  3. 2. Pathophysiological and Histomorphological Effects of One-Lung Ventilation in the Porcine Lung

    Författare :Alf Kozian; Göran Hedenstierna; Thomas Hachenberg; Filip Freden; Sten Walther; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alveolar Recruitment Manoeuvre; One-Lung Ventilation; Lung Protective Ventilation; Tidal Volume; Computed Tomography; Tidal Recruitment; Animal Model; Open Thoracic Surgery; Ventilation Perfusion Distribution; Single Photon Emission Computed Tomography; Diffuse Alveolar Damage; Medical laboratory science; Medicinsk laboratorievetenskap; Anestesiologi; Anaesthesiology;

    Sammanfattning : Thoracic surgical procedures require partial or complete airway separation and the opportunity to exclude one lung from ventilation (one-lung ventilation, OLV). OLV is commonly associated with profound pathophysiological changes that may affect the postoperative outcome. LÄS MER

  4. 3. The Effect of CO2-Pneumoperitoneum on Ventilation Perfusion Distribution of the Lung

    Författare :Christof Strang; Göran Hedenstierna; Suzanne Odeberg-Wernerman; Uppsala universitet; []
    Nyckelord :lung; atelectasis; computed tomography; multiple inert gas elimination technique; model; pig; Pa–ECO2 ratio; surgery; laparoscopy; lung; blood flow; single photon emission computed tomography; ventilation perfusion distribution; gas exchange; hypoxic pulmonary vasoconstriction; MEDICINE; MEDICIN;

    Sammanfattning : Laparoscopic operations are a common and popular way for abdominal procedures. They are usually performed by insufflation of carbon dioxide (CO2) into the abdominal cavity. However, insufflation of CO2 may interfere with cardiac and circulatory as well as respiratory functions. The CO2-pneumoperitoneum (PP) may cause hypercarbia and acidosis. LÄS MER

  5. 4. Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

    Författare :Anna Hogmalm; Göteborgs universitet; []
    Nyckelord :bronchopulmonary dysplasia; transgenic mice; inflammation; lung; interleukin-1; αvβ6 integrin; mmp-9; surfactant;

    Sammanfattning : Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD. LÄS MER

  7. 5. The Immune Response to One-Lung Ventilation : Clinical and Experimental Studies

    Författare :Thomas Schilling; Göran Hedenstierna; Hans Hedenström; Thomas Hachenberg; Sven-Erik Ricksten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; One-lung ventilation; open thoracic surgery; ventilation-induced lung injury; alveolar immune response; bronchoalveolar lavage; propofol; desflurane; cytokines; animal model; mRNA; RT-PCR; Medical laboratory science; Medicinsk laboratorievetenskap; anestesiologi; Anaesthesiology;

    Sammanfattning : One-lung ventilation (OLV) as an established procedure during thoracic surgery may be injurious in terms of increased mechanical stress characterised by alveolar cell stretch and overdistension, increased cyclic tidal recruitment of alveolar units, compression of alveolar vessels and increased pulmonary vascular resistance. This may result in ventilation-induced lung injury with pro-inflammatory cytokine production, leukocyte recruitment and neutrophil-dependent tissue destruction. LÄS MER