Sökning: "lung mechanics"

Visar resultat 6 - 10 av 56 avhandlingar innehållade orden lung mechanics.

  1. 6. Pathogenesis and treatment of chemical-induced lung injury

    Författare :Elisabeth Wigenstam; Anders Bucht; Thomas Sandström; Kjell Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemical-induced lung injury; dexamethasone; melphalan; vitamin E; respiratory mechanics; lungmedicin; Lung Medicine;

    Sammanfattning : Inhalation of chemical substances can cause irritation to airways and in high doses acute airway injury. When mice are exposed to the alkylating nitrogen mustard analogue melphalan they develop an acute airway inflammation with a rapid influx of neutrophils to the lungs. LÄS MER

  3. 7. Airway mechanics of mice and men

    Författare :Lennart Lundblad; Malmö Klinisk fysiologi och nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; radiologi; tomografi; tomography; medical instrumentation; Clinical physics; Medicin människa och djur ; Medicine human and vertebrates ; Penh; emphysema; airway resistance; gas conditioning; plethysmography; lung mechanics; Boyle s law; Physiology; medicinsk instrumentering; Klinisk fysiologi; radiology; enhanced pause; pulmonary fibrosis; micro computed tomography; forced oscillation technique; COPD;

    Sammanfattning : In this thesis we explore and further develop several techniques used in the animal laboratory as well as in the clinical setting. In particular, we expand the understanding and usefulness of plethysmographic techniques in small rodents. LÄS MER

  4. 8. Titrating Open Lung PEEP in Acute Lung Injury : A clinical method based on changes in dynamic compliance

    Författare :Fernando Suarez Sipmann; Göran Hedenstierna; Hans Hedenström; Stefan Lundin; Uppsala universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; PEEP; open lung; recruitment; dead space; electrical impedance tomography; ARDS.; Medicine; Medicin;

    Sammanfattning : The recognition that supportive mechanical ventilation can also damage the lung, the so called ventilation induced lung injury (VILI), has revived the more than 40 year long debate on the optimal level of PEEP to be used. It is established that the prevention of VILI improves patient outcome and that PEEP exerts protective effects by preventing unstable diseased alveoli from collapsing. LÄS MER

  5. 9. Cross-modal Imaging in Lung Research: From µCT dosimetry to synchrotron phase contrast microtomography biomechanical insights in preclinical lung injury models

    Författare :Richard Deyhle Jr; Malmö Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thermoluminescent Dosimetry; Optically stimulated luminescence OSL ; Computed tomography CT ; 4DCT; Phantoms; Imaging; X-rays; pre-clinical models; Pre-clinical; dosimetry: physical basis; biomedical strain; lung injury; mechanical ventilation; inflammation; lung function; synchrotron; histology; acute respiratory distress syndrome ARDS ; Ventilator Inudced Lung Injury VILI ; Histology; Forced Oscillation Technique FOT ; Divergence Theorem; Registration techniques;

    Sammanfattning : Lung diseases continue to present a large burden to public health, especially in industrialized countries. For abetter understanding of the underlying patho-mechanisms in lung related diseases as well as for testing theefficacy of novel therapies, preclinical studies in animal models are indispensable. LÄS MER

  7. 10. Regional Lung Mechanics and Influence of an Active Diaphragm in Experimental Lung Injury

    Författare :Mariangela Pellegrini; Anders Sune Larsson; Göran Hedenstierna; Michael Quintel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute respiratory distress syndrome; artificial respiration; diaphragm; pulmonary atelectasis; lung imaging; respiratory system; animal model; Fysiologi; Physiology; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Despite being an essential life-support strategy in severe respiratory failure, mechanical ventilation can, if not optimally set and monitored, lead to injury of the lung parenchyma and diaphragm. These conditions are called ventilator-induced lung injury and ventilator-induced diaphragmatic dysfunction (VIDD), respectively. LÄS MER