Sökning: "low-sample"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet low-sample.

1. 1. Comparative network analysis of human cancer: sparse graphical models with modular constraints and sample size correction

   Författare :José Sánchez; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer.; fused lasso;

   Sammanfattning : In the study of transcriptional data for different groups (e.g. cancer types) it's reasonable to assume that some dependencies between genes on a transcriptional or genetic variants level are common across groups. Also, that this property is preserved locally, thus defining a modular structure in the model networks. LÄS MER

3. 2. Network models with applications to genomic data: generalization, validation and uncertainty assessment

   Författare :José Sánchez; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inverse covariance matrix; precision matrix; graphical models; high-dimension; low-sample; networks; sparsity; fused lasso; elastic net; cancer; TCGA pan cancer analysis; online resource; discriminant analysis; classification; networks;

   Sammanfattning : The aim of this thesis is to provide a framework for the estimation and analysis of transcription networks in human cancer. The methods we develop are applied to data collected by The Cancer Genome Atlas (TCGA) and supporting simulations are based on derived models in order to reflect real data structure. LÄS MER

4. 3. Development of new methods for miniaturized separation techniques

   Författare :Marcus Öhman; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

   Sammanfattning : The aim of this study has been to develop and investigate separation methods for miniaturized systems. Micro liquid chromatography was coupled on-line with a mass spectrometer equipped with an electrospray ionization source for the separation and characterization of flavonoids in Citrus juices. LÄS MER

5. 4. Methods for protein analysis by capillary electrophoresis and mass spectrometry

   Författare :Joakim Romson; Åsa Emmer; Peter Dinér; Lukas Käll; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MALDI; Concentration plates; Alkyl ketene dimer; CE-MALDI-MS2; On-target digestion; Automation; Robot; Pieris napi; spermatophore; ESI-MS2; Osteopontin; MALDI; Koncentrationsprovplatta; alkylketenedimer; CE-MALDI-MS2; enzymklyvning på provplatta; Automatisering; Robot; Pieris napi; Spermatofor; ESI-MS2; Osteopontin; Kemi; Chemistry;

   Sammanfattning : Protein analysis is important to understanding biological systems, but sample diversity necessitates a multitude of analysis techniques and methods. Challenges that are addressed include analysis of low abundance samples, fractionation to reduce sample complexity, and automation to reduce time and cost. LÄS MER

7. 5. Method development for affinity capillary electrophoresis of ß2-glycoprotein I and biological ligands

   Författare :Maria E. Bohlin; Lars G Blomberg; Niels H H Heegaard; Jan Leo Reubsaet; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Capillary Electrophoresis; β2-glycoprotein I; acidic pretreatment; pH hysteresis effect; Affinity Capillary Electrophoresis; Kemi; Chemistry;

   Sammanfattning : The final goal of this study is to establish a microscale analysis method that allows solution phase characterization of interactions between β2-glycoprotein I (β2gpI) and some of its ligands. Human β2gpI is a phospholipid- and heparin-binding plasma glycoprotein. LÄS MER