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Visar resultat 1 - 5 av 98 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Ligand binding and enzyme catalysis studied by molecular dynamics simulations

    Författare :Tomas Hansson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; molecular dynamics simulation; free energy; linear response; drug design; empirical valence bond; HIV protease; protein tyrosine phosphatase; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Molecular dynamics simulations and free energy calculations can be applied to biomolecular systems to predict ligand binding affinities. Combined with hybrid quantum-classical potential energy surfaces, such computations can also be used to probe enzymatic catalysis mechanisms. LÄS MER

  3. 2. Towards bacterial valorization of low molecular weight lignin

    Författare :Krithika Ravi; Avdelningen för kemiteknik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pseudomonas putida; Microbacterium sp.; Guaiacol; Syringate; Kraft lignin; Bioconversion; Biorefineries;

    Sammanfattning : Lignin is one of the major constituents in lignocellulosic biomass and is the mostabundant source of renewable aromatics on terrestrial ecosystems. The workcarried out in this thesis concerns bacterial conversion of low molecular weightlignin. LÄS MER

  4. 3. Non-invasive monitoring of low molecular weight biomarkers relevant to skin inflammation and cancer

    Författare :Skaidre Jankovskaja; Tautgirdas Ruzgas; Johan Engblom; György Marko-Varga; Melinda Rezeli; Pawel Lukasz Urban; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tryptophan; Kynurenine; Phenylalanine; Tyrosine; Low molecular Weight Biomarkers; Non-Invasive; Skin Surface Sampling; Skin Permeability; Hydrogels; Prussian White; Health and society; Hälsa och samhälle;

    Sammanfattning : Development of skin inflammation and cancer in viable epidermis and dermis involve slow molecular weight (LMW) metabolites. We hypothesize that these LMW compounds can be collected on the surface of the skin and used for non-invasive diagnostics of skin disorders. LÄS MER

  5. 4. Low Molecular Weight Organic Acids and Their Aluminium Complexes in Forest Soils

    Författare :Patrick van Hees; F. C. Ugolini; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The significance of low molecular weight (LMW) organic acids and their aluminium (Al) complexes in soil solutions of podzolized soils was examined. Methods for the analysis of these compounds and complexes were developed, and the impact of these substances on the weathering and podzolization processes was studied. LÄS MER

  7. 5. Molecular Approaches to Explore Drug-Target Interactions

    Författare :Abdullah Al-Amin; Ulf Landegren; Christopher Schofield; Uppsala universitet; []
    Nyckelord :Drug discovery; target engagement; target engagement-mediated amplification; cellular thermal shift assay; proximity extension assay; in situ PLA; high-content imaging; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Improved means to assess the clinical potential of drug candidates can critically influence development of new therapeutic entities, a central aim in medical life science. Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. LÄS MER