Sökning: "low LET"
Visar resultat 1 - 5 av 67 avhandlingar innehållade orden low LET.
1. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses
Sammanfattning : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. LÄS MER
2. Cellular effects after exposure to mixed beams of ionizing radiation
Sammanfattning : Mixed beams of ionizing radiation in our environment originate from space, the bedrock and our own houses. Radiotherapy patients treated with boron neutron capture therapy or with high energy photons are also exposed to mixed beams of gamma radiation and neutrons. LÄS MER
3. Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells
Sammanfattning : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. LÄS MER
4. Radiobiological investigations of proton and light ion therapy
Sammanfattning : During the last decade, the interest in proton and light ion beam therapy has increased considerably and several new centres are planned around the world. These particles have a large advantage due to their sharp physical dose distributions as compared to conventional radiotherapy beams. LÄS MER
5. Radiotherapy Gel Dosimetry: Development and Application of Normoxic Polymer Gels
Sammanfattning : In many radiotherapy applications, true three-dimensional dosimetry with good spatial resolution that can be achieved in a single measurement would be of great value. Polymer gel dosimetry fulfils many of the demands on such a system. In this study, methods to facilitate the implementation of gel dosimetry have been investigated. LÄS MER