Sökning: "lorlatinib"

Hittade 4 avhandlingar innehållade ordet lorlatinib.

  1. 1. Förbättrad radionuklidterapi av neuroblastom

    Författare :Arman Romiani; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radionuclide therapy; Neuroblastoma; Somatostatin analog; 177Lu-octreotate; 177Lu-octreotide; Lorlatinib; Combination therapy; Radiosensitizer;

    Sammanfattning : Today, about half of the children diagnosed with high-risk neuroblastoma (HR-NB) survive due to considerable treatment improvements during the last decades. However, there is still much to be done for the other half who are not cured with current treatments. LÄS MER

  3. 2. Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer

    Författare :Abdulmalik Bokhari; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Zfp148; TP53; ALK; EML4-ALK; brigatinib; lorlatinib; RRM2; alectinib;

    Sammanfattning : Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric patients. LÄS MER

  4. 3. Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma

    Författare :Muhammad Wasi Alam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Oncology; Anaplastic lymphoma kinase ALK ; Dihydroorotate Dehydrogenase DHODH ;

    Sammanfattning : Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells of the sympathetic nervous system. LÄS MER

  5. 4. Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation

    Författare :Joachim T. Siaw; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; ALK; 11q.; DLG2; SP1; differentiation; crizotinib; ceritinib; brigatinib;

    Sammanfattning : Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. LÄS MER