Sökning: "long non-coding RNAs lncRNAs"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden long non-coding RNAs lncRNAs.

1. 1. Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation

   Författare :Panagiotis Papoutsoglou; Aristidis Moustakas; Carl-Henrik Heldin; Peter Zaphiropoulos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; signal transduction; long non-coding RNAs; ADP-ribosylation; transcriptional regulation; chromatin remodeling; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. LÄS MER

3. 2. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

   Författare :Sanhita Mitra; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

   Sammanfattning : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. LÄS MER

4. 3. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

   Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

5. 4. Functional analysis of long non-coding RNAs in cancer

   Författare :Linda Vidarsdottir; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives and prompted scientists to further look into the involvement of noncoding RNAs (ncRNAs) in development and disease. LÄS MER

7. 5. Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation

   Författare :Samudyata Samudyata; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile regulators of gene expression, amidst skepticism regarding the biological usefulness of pervasive genomic transcription and its non-coding RNA products prevalent in most eukaryotes. LÄS MER