Sökning: "loci method"

Visar resultat 1 - 5 av 84 avhandlingar innehållade orden loci method.

  1. 1. Det aristoteliska historiebegreppet. Historieteori i renässansens Europa och Sverige

    Författare :Per Landgren; Göteborgs universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; Aristotelian concept of history; atemporal history; sequential concept of history; history as discipline; natural history; knowledge of particulars; natural philosophy; scientific knowledge; Aristotelian theory of science; dual structure of science; loci-method; true induction; axiom; intellectual instrumental habitus.;

    Sammanfattning : .... LÄS MER

  3. 2. Numerical Algorithms for Optimization Problems in Genetical Analysis

    Författare :Kateryna Mishchenko; Sverker Holmgren; Dmitrii Silvestrov; Lars Rönnegård; Ann-Charlotte Berglund Sonnhammer; Mälardalens högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantitative Trait Loci QTL ; restricted maximum likelihood REML ; variance components; average information AI matrix; Local optimization; Quasi-Newton method; Active Set method; Hessian approximation; BFGS update; Applied mathematics; Tillämpad matematik; Matematik tillämpad matematik;

    Sammanfattning : The focus of this thesis is on numerical algorithms for efficient solution of QTL analysis problem in genetics.Firstly, we consider QTL mapping problems where a standard least-squares model is used for computing the model fit. LÄS MER

  4. 3. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Författare :Lars Ängquist; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Sammanfattning : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. LÄS MER

  5. 4. Positional cloning of polymorphic loci that control autoreactive T cells

    Författare :Mike Aoun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are expensive diseases, both financially and socially, because they are in most cases life long and require a long-lasting treatment. They can also be life threatening, as they are among top 10 causes of death in women and therefore, they represent a serious clinical problem and require careful medical management. LÄS MER

  7. 5. Numerical Algorithms for Mapping of Multiple Quantitative Trait Loci in Experimental Populations

    Författare :Kajsa Ljungberg; Sverker Holmgren; Örjan Carlborg; Margot Gerritsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Scientific computing; Beräkningsvetenskap; Scientific Computing;

    Sammanfattning : Most traits of medical or economic importance are quantitative, i.e. they can be measured on a continuous scale. Strong biological evidence indicates that quantitative traits are governed by a complex interplay between the environment and multiple quantitative trait loci, QTL, in the genome. LÄS MER