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Visar resultat 1 - 5 av 26 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Zinc in folding and misfolding of SOD1 : Implications for ALS

   Författare :Lina Leinartaité; Mikael Oliveberg; Bengt-Harald Jonsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein misfolding; local unfolding; metal binding; energy landscape; protein disease; amyotrophic lateral sclerosis; Biochemistry; biokemi;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). LÄS MER

3. 2. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

   Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

   Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER

4. 3. Peptide folding and local unfolding of SOD1 in the presence of interacting macromolecular crowders - a Monte Carlo approach

   Författare :Anna Bille; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo simulations; protein folding; SOD1; crowding; Fysicumarkivet A:2016:Bille;

   Sammanfattning : A protein chain often folds into a functional, specific three dimensional structure. Failurein this process can in some cases lead to disease, e.g. the misfolding disease ALS. LÄS MER

5. 4. On the mechanism of Urea-induced protein denaturation

   Författare :Matteus Lindgren; Per-Olof Westlund; Arnold Maliniak; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemical denaturation; Protein unfolding; urea; MD simulations; NMR spectroscopy; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

   Sammanfattning : It is well known that folded proteins in water are destabilized by the addition of urea. When a protein loses its ability to perform its biological activity due to a change in its structure, it is said to denaturate. LÄS MER

7. 5. Unfolding Evolutionary Growth Within a Subsidiary: The Case of a Sales Subsidiary in the Middle East

   Författare :Johan Jakobsson; Göteborgs universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Evolutionary Growth; Capabilities; Multinational Corporation; Resource Management; Subsidiary; Subsidiary Charter; Subsidiary Evolution;

   Sammanfattning : Subsidiaries are important entities in multinational corporations and are typically established with predetermined business responsibilities. A subsidiary responds to actors in the internal network (e.g. , HQs and other subsidiaries) as well as actors in the external network (e. LÄS MER