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Visar resultat 1 - 5 av 22 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

    Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

    Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER

  3. 2. Cell cycle regulation in cancer: A noncoding perspective

    Författare :Mohamad Ali; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long Noncoding RNA; lncRNA; Cell cycle; S phase; Mitosis; Checkpoint; Cancer; SCAT7; LY6K-AS;

    Sammanfattning : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. LÄS MER

  4. 3. Regulatory Roles of Noncoding RNA in Development and Disease

    Författare :Gaurav Kumar Pandey; Chandrasekhar Kanduri; Claes Wadelius; Karl Ekwall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Noncoding RNA; Genomic Imprinting; Epigenetics; Neuroblastoma;

    Sammanfattning : Long noncoding RNAs (lncRNAs) are being realized as important players in gene regulation and their misregulation has been considered as one of the underlying causes for tumor initiation and progression in many human pathologies. In the current thesis, I have addressed the functional role of lncRNAs in development and disease model systems. LÄS MER

  5. 4. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

    Författare :Sanhita Mitra; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

    Sammanfattning : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. LÄS MER

  7. 5. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER