Sökning: "liver"

Visar resultat 36 - 40 av 1292 avhandlingar innehållade ordet liver.

1. 36. Decellularized liver extracellular matrix as a 3D scaffold for bioengineering applications

   Författare :Vamakshi Khati; Aman Russom; Håkan Jönsson; Giulia Gaudenzi; Ana Teixeira; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; liver decellularization; decellularized liver matrix bioink; bioprinting; sacrificial scaffold; viscoelasticity; bioengineering; tumor modeling; stem cell differentiation; bioreactor; Biotechnology; Bioteknologi;

   Sammanfattning : The increasing global burden of end-stage liver disease has increased the need for liver transplantation, the definitive cure. However, there is a huge discrepancy between the number of available organ donors and the number of patients waiting for transplantation, resulting in the deaths of a significant number of patients on the waiting list as only 10% of the global need for transplantation is met. LÄS MER

3. 37. Renal function after transplantation of the liver and intestine

   Författare :Gustaf Herlenius; Göteborgs universitet; []
   Nyckelord :adult liver transplantation; pediatric liver transplantation; intestinal transplantation; multivisceral transplantation; immunosuppression; calcineurin inhibitors; glomerular filtration rate; renal function; nephrotoxicity; chronic kidney disease; renal replacement therapy; mortality;

   Sammanfattning : Background: Chronic kidney disease (CKD) after liver (LT) or intestinal (IT) transplantation may decrease patient survival. Calcineurin inhibitors (CNI) play a major role in its development. Aims: Describe long term renal function and risk factors for developing CKD in adults and children after LT and IT. LÄS MER

4. 38. Immune interactions with the liver

   Författare :Azza Karrar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Liver sinusoid; endothelial cells; apoptosis; antibodies; liver immunity; biliary cells; autoimmune liver diseases; estrogen;

   Sammanfattning : The liver has an important role in the induction of immune tolerance and can be a target for immune mediated damage. The following studies are performed to address the role of liver sinusoidal endothelial cells (LSEC) in tolerance induction and to understand some of the mechanisms involved in the pathogenesis of primary sclerosing cholangitis (PSC). LÄS MER

5. 39. Proteomics-informed analysis of drug disposition in the human liver and small intestine

   Författare :Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER

7. 40. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

   Författare :Julia Nilsson; Autoimmunitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

   Sammanfattning : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. LÄS MER