Sökning: "liver toxicity"

Visar resultat 6 - 10 av 91 avhandlingar innehållade orden liver toxicity.

  1. 6. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

    Författare :Jenny M. Pedersen; Per Artursson; Christel A. S. Bergström; Stefan Oswald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER

  3. 7. Prevention of liver cancer in chronic liver disease : an experimental study of sodium selenite and rat hepatocarcinogenesis

    Författare :Suvd Erkhembayar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium treatment in supranutritional but subtoxic doses has previously been shown to inhibit cell proliferation in preneoplastic lesions in a rat liver carcinogenesis model. The mechanisms are not known, but thioredoxin reductase (TrxR1), a seleno-enzyme essential for maintaining intracellular redox status and cellular defence against oxidative stress might be involved. LÄS MER

  4. 8. The toxicity of perfluoroalkyl acids in zebrafish (Danio rerio)

    Författare :Mazhar Ul haq; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Perfluoroalkyl acids (PFAAs) are globally distributed synthetic chemicals. Their unique properties make them widely used, in industry and elsewhere. These are a group of compounds with varying carbon chain lengths and functional groups. The toxicity evaluation of PFAAs is important to better assess their organismal and environmental impact. LÄS MER

  5. 9. Cumulative assessment of persistent organic pollutant toxicity in vivo

    Författare :Emma Westerholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Humans are continuously exposed to a multitude of compounds present in the environment and in food. A major challenge in risk assessment is to determine the degree of exposure to multiple chemicals and the hazards associated with such combined exposure. LÄS MER

  7. 10. Radiation therapy of upper gastrointestinal cancers with scanned proton beams : A treatment planning study

    Författare :Gracinda Mondlane; Albert Siegbahn; Michael Gubanski; Iuliana Toma-Dasu; Crister Ceberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Treatment planning; gastric cancer; liver metastases; photon beam therapy; proton beam therapy; dosimetric comparison; normal tissue complication probability; risk of radiation-induced secondary cancer; patient selection; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : Proton beam therapy (PBT), using scanned beams, is an emerging modality used for the treatment of cancer. The clinical advantages of PBT, compared to commonly used photon beam therapy, have been demonstrated in different studies. LÄS MER