Sökning: "liver toxicity"

Visar resultat 21 - 25 av 91 avhandlingar innehållade orden liver toxicity.

  1. 21. Hepatitis C virus infection in patients receiving opiate substitution therapy in Sweden

    Författare :Anna Jerkeman; Enheten för infektionssjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The hepatitis C virus (HCV) is a blood borne virus effectively spread through injection practices. Consequently, people who inject drugs (PWID) are at the center of the current HCV epidemic in industrialized countries, with regards both to prevalence and incidence. LÄS MER

  3. 22. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

    Författare :Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

    Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER

  4. 23. Studies on genetic hemochromatosis and the hepatotoxicity of iron

    Författare :Karin Hagen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this study was to investigate the mutations and clinical expression of genetic hemochromatosis in patients and mechanisms involved in the hepatotoxicity of iron in animal and cell- culture models. In Swedish patients with a clinical diagnosis of genetic hemochromatosis, the C282Y mutation of the HFE gene was present in 94. LÄS MER

  5. 24. Translational Tumor Drug Delivery : Doxorubicin formulation performance, intracellular uptake and molecular diffusion

    Författare :Oliver Degerstedt; Hans Lennernäs; Erik Sjögren; Per Hansson; Jessica Rosenholm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; doxorubicin; drug diffusion; cellular uptake; drug delivery; PBPK modelling; hepatocellular carcinoma; emulsion; IC50; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Globally, hepatocellular carcinoma (HCC) is the most common form of liver cancer and a leading cause of cancer death. One important risk factor is liver cirrhosis and the disease progression is characterized by deposition of extracellular matrix proteins that form a fibrous network, which increases liver stiffness and may limit the effectiveness of different treatment strategies. LÄS MER

  7. 25. Charcterization of biotransformation systems in human cells

    Författare :Therese Söderdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Efforts are continuously being made to improve test procedures so that predictions of toxicity can be made earlier and more accurately. Understanding mechanisms of toxicity is an important part of improving safety assessment, but for this, simplified methods and models to screen for mechanisms associated with toxicity are required. LÄS MER