Sökning: "liver toxicity"

Visar resultat 1 - 5 av 75 avhandlingar innehållade orden liver toxicity.

  1. 1. Proteomics informed investigation of human hepatocytes and liver tissue

    Författare :Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER

  2. 2. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    Författare :Anna Franzén; Eva Brittebo; Ingvar Brandt; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER

  3. 3. Small bowel obstruction and toxicity of a new model of adhesion prevention

    Författare :Karolin Isaksson; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small bowel obstruction; predictive parameters; appendectomy; open versus laparoscopic; abdominal adhesions; prevention; polypeptides; toxicity; biodistribution;

    Sammanfattning : Abstract Background: Small bowel obstruction (SBO) is a common surgical diagnosis. If no signs of strangulation are evident, the majority of the patients can be conservatively managed. Approximately one third of the patients need surgical treatment and there is a need for early parameters that can predict operative intervention. LÄS MER

  4. 4. Therapy with 177Lu-octreotate - pharmacokinetics, dosimetry and kidney toxicity

    Författare :Maria Larsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; 177Lu-octreotate; 111In-octreotide; dosimetry; biokinetics; scintigraphy; conjugate view method; renal function; renal toxicity; lysine; DMSA; 99mTc-DTPA; 99mTc-DMSA;

    Sammanfattning : 177Lu-octreotate is used for treatment of patients with somatostatin receptor expressing neuroendocrine tumors in some clinics using a standard schedule. Renal and bone marrow toxicity are the main limiting factors. LÄS MER

  5. 5. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

    Författare :Jenny M. Pedersen; Per Artursson; Christel A. S. Bergström; Stefan Oswald; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER