Sökning: "liver function"

Visar resultat 16 - 20 av 340 avhandlingar innehållade orden liver function.

  1. 16. Immune interactions with the liver

    Författare :Azza Karrar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver sinusoid; endothelial cells; apoptosis; antibodies; liver immunity; biliary cells; autoimmune liver diseases; estrogen;

    Sammanfattning : The liver has an important role in the induction of immune tolerance and can be a target for immune mediated damage. The following studies are performed to address the role of liver sinusoidal endothelial cells (LSEC) in tolerance induction and to understand some of the mechanisms involved in the pathogenesis of primary sclerosing cholangitis (PSC). LÄS MER

  3. 17. Proteomics-informed analysis of drug disposition in the human liver and small intestine

    Författare :Christine Wegler; Per Artursson; Pär Matsson; Tommy B Andersson; Manthena Varma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER

  4. 18. Magnetic resonance imaging for the assessment of liver function

    Författare :Henrik Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DHCE-MRI;

    Sammanfattning : This thesis presents dynamic hepatocyte-specific contrast-enhanced magnetic resonance imaging (DHCE-MRI) as a new method for total and segmental liver function assessment. The method is based on the hepatocyte-specific properties of Gd- EOB-DTPA, which is actively taken up into functioning hepatocytes. LÄS MER

  5. 19. On CXC Chemokines in Endotoxin-Induced Liver Injury

    Författare :Xiang Li; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ortopedi; traumatologi; orthopaedics; traumatology; Kirurgi; Surgery; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; intravital microscopy; liver damage; Adhesion; CXC chemokines;

    Sammanfattning : Leukocyte recruitment is a rate-limiting step in endotoxemic liver injury. Leukocyte extravasation is a multistep process, supported by multiple combinations of adhesion molecules and chemokine receptors. This thesis examined the mechanisms of activation, adhesion and extravascular infiltration of leukocytes in endotoxin-induced liver injury. LÄS MER

  7. 20. Renal injury in liver transplantation clinical and mechanistic studies

    Författare :Åsa Norén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver transplantation; Renal injury; Ischemia reperfusion injury;

    Sammanfattning : ABSTRACT Background: Renal injury in liver transplantation (LT) is common and presents both as early and late insufficiency. These conditions are interconnected and have substantial impact on the long-term outcome. LÄS MER