Sökning: "lithocholic acid"

Hittade 4 avhandlingar innehållade orden lithocholic acid.

  1. 1. Hydrophobic interactions of serpins

    Detta är en avhandling från Sabina Janciauskiene, Wallenberglab, University Hospital Malmö, S-20502 Malmö, Sweden

    Författare :Sabina Janciauskiene; Lunds universitet.; Lund University.; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteiner; enzymology; polymerization.; Proteins; conformational polymorphism; hydrophobic interaction; amyloid fibrils; Alzheimer`s peptide Ab; alpha-1-antichymotrypsin; C-terminal peptide; lithocholic acid; cholesterol; Key words: alpha-1-antitrypsin; bile acids; enzymologi;

    Sammanfattning : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. LÄS MER

  2. 2. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Carl-Gustaf Hillebrant; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

    Sammanfattning : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. LÄS MER

  3. 3. Cytochrome P450 enzymes in the biosynthesis and metabolism of bile acids and active forms of vitamin D

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Zufan Araya; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Cytochrome P450 enzymes catalyzing hydroxylations in the biosynthesis and metabolism of bile acids and active forms of vitamin D3 were studied.A microsomal cytochrome P450 enzyme with a molecular mass of 53 kDa, catalyzing the 6α-hydroxylation of taurochenodeoxycholic acid was purfied from pig liver microsomes and characterized with respect to catalytic and electrophoretic properties as well as polyclonal antibodies. LÄS MER

  4. 4. Toxicological aspects of bile acids and human fecal water on cultered human colon carcinoma cells

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medical Nutrition

    Författare :Björn Glinghammar; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Colorectal tumorigenesis involves activation of mutations in proto-oncogenes, such as ras and c-myc, as well as mutations that inactivate tumor suppressor genes including the APC and the p53 gene. These genetic events, in turn, lead to epigenetic changes in signal transduction pathways, which regulate processes such as cell proliferation, differentiation and apoptosis. LÄS MER