Sökning: "liquid biopsy"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden liquid biopsy.

  1. 1. Circulating platelets : a novel liquid biopsy source for cancer diagnostics and therapy stratification

    Författare :Lee-Ann Tjon-Kon-Fat; Jonas Nilsson; Pernilla Wikström; Michiel Pegtel; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; biomarkers; liquid biopsy; therapy stratification; personalised medicine; Prostate cancer;

    Sammanfattning : As conventional tissue biopsies have several drawbacks, much effort has been directed toward the development of minimal-invasive liquid biopsy platforms for detecting and profiling cancer.Platelets are the second most abundant cells in blood and have very versatile functions both in physiological and pathophysiological conditions. LÄS MER

  2. 2. Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine

    Författare :Gustav Johansson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liquid biopsy; cell-free DNA; immune repertoire; next-generation sequencing; unique molecule identifier; GIST; γδ T cell;

    Sammanfattning : Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid biopsies, cell-free DNA is present at low concentrations, contains minute tumor allele frequencies, and is highly fragmented. LÄS MER

  3. 3. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia

    Författare :Yilun Chen; Translational Oncogenomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Breast cancer; AML; PTEN; PI3K; Liquid biopsy; Sequencing; cfDNA; ctDNA; Structural variants; Mammography; CTC; Mutation detection; IBSAFE; MRD;

    Sammanfattning : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. LÄS MER

  4. 4. Distribution, total number and size of different types of fibres in male and female skeletal muscles : an enzyme histochemical study of whole muscle cross-sections

    Författare :Karin Henriksson-Larsén; Umeå universitet; []
    Nyckelord :Muscle biopsy; human; enzyme histochemistry;

    Sammanfattning : In order to investigate the total number, relative proportions, size variations and distribution patterns of fibres of different types in human skeletal muscles, a technique was developed which allows whole muscle cross-sections to be collected and stained enzyme histochemically. Necropsy material was obtained from m. tibialis anterior and m. LÄS MER

  5. 5. Harnessing urinary extracellular vesicles microRNA by acoustic trapping as potential biomarkers for prostate cancer

    Författare :Anson Ku; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Prostate cancer (PCa) is an interesting study case of clinical management of uncertainty. PCa is the most diagnosed but only the second-leading cause of non-cutaneous cancer-related mortalities among men in developed countries. To put simply, the life-time risk of PCa diagnosis and mortality is approximately 11% and 3% respectively; a ~3. LÄS MER