Sökning: "lipoxygenase"

Visar resultat 16 - 20 av 75 avhandlingar innehållade ordet lipoxygenase.

  1. 16. Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1 in hematopoietic cells

    Författare :Erik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Arachidonic acid is a polyunsaturated fatty acid that has four double bonds and belongs to the omega-6 family of fatty acids. Although it can be formed in humans from one essential fatty acid (linoleic acid), most of the arachidonic acid in the body comes with the intake of food. LÄS MER

  3. 17. New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11

    Författare :Xiao Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) translocation which results in overexpression of nuclear cyclin D1. LÄS MER

  4. 18. 5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP

    Författare :Tove Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :non-heme iron centre; ATP binding; Ca2 binding; C2 domain;

    Sammanfattning : Human 5-lipoxygenase (5LO) is a monomeric non-heme iron enzyme, which catalyses the first two steps in the biosynthesis of leukotrienes: oxygenation of arachidonic acid to yield 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HPETE) and the subsequent dehydration to form the unstable epoxide intermediate 5(S)-trans-5,6-oxido7,9-trans-11,14-cis-eicosatetraenoic acid. The latter compound (leukotriene A4), is the precursor of the biologically active leukotrienes B4, C4, D4 and E4, which are regarded as critical mediators in asthma and other inflammatory and allergic disorders. LÄS MER

  5. 19. Endothelial cell interactions with neutrophils : studies of adhesion and effects of lipoxygenase metabolites and antirheumatic drugs

    Författare :Mikael Heimbürger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion; auranofin; endothelium; gold sodium thiomalate; leukotrienes; lipoxins; neutrophils; PPAR; prednisolone;

    Sammanfattning : Inflammation is a process of vital importance in the defence and elimination of microorganisms as well as in the repair of the damaged tissue. However, inadequate or excessive inflammation leads to inflammatory diseases such as rheumatoid arthritis. LÄS MER

  7. 20. Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : method development and clinical applications

    Författare :Flora Gaber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Airway inflammation; aspirin-intolerant asthma; biomarker; exhaled breath condensate; FENO; induced sputum; leukotrienes; 5-lipoxygenase; non-invasive analysis; saliva;

    Sammanfattning : Asthma and chronic obstructive pulmonary disease (COPD) are two common diseases characterized by chronic airway inflammation, but the inflammation in asthma is different from the one in COPD. In addition, asthma is a heterogeneous disease presenting with many different phenotypes (e.g. LÄS MER