Sökning: "lipoxygenase"

Visar resultat 11 - 15 av 75 avhandlingar innehållade ordet lipoxygenase.

  1. 11. Studies on cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in lymphomas

    Författare :Frida Schain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Classical Hodgkin lymphoma (cHL) is a malignant disorder with striking inflammatory features. Since cysteinyl leukotrienes (cysLTs) are potent inflammatory mediators it was of interest to study their potential role in the pathogenesis of cHL. LÄS MER

  3. 12. Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation

    Författare :Cheng Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various physiological and pathophysiological activities including inflammation, apoptosis, cell maturation and tumorigenesis. LÄS MER

  4. 13. Studies on the activation of cytosolic phospholipase A2 and 15-lipoxygenase-1

    Författare :Erik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Arachidonic acid is a polyunsaturated fatty acid, which has four double bonds and belongs to the omega-6 family of fatty acids. Even if it can be formed in humans from one essential fatty acid, the linoleic acid, most of the arachidonic acid in the body comes with the intake of food. LÄS MER

  5. 14. Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodgkin lymphoma

    Författare :Frida Schain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Classical Hodgkin lymphoma (cHL) is histologically characterized by a minority of malignant cells, the so-called Hodgkin-Reed Sternberg (H-RS) cells, surrounded by inflammatory cells such as T lymphocytes, eosinophils, macrophages and mast cells. It is generally believed that various molecules released by the H-RS cells are of major importance in the pathophysiology of cHL. LÄS MER

  7. 15. Effects of hypoxia on macrophage function in atherosclerosis

    Författare :Ellen Knutsen Rydberg; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; macrophage; IL-8; oxidized LDL; oxysterols; 15-lipoxygenase-2;

    Sammanfattning : Atherosclerosis is a complex disease, which affects large and medium sized arteries and is characterized by an arterial wall thickening. A constant supply of oxygen is needed to maintain cell functions in the atherosclerotic plaque. The oxygen distribution to the cells in the arterial wall depends on diffusion. LÄS MER