Sökning: "lipogenic genes"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden lipogenic genes.

  1. 1. Growth hormone and PPARalpha in the regulation of genes involved in hepatic lipid metabolism

    Författare :Caroline Améen; Göteborgs universitet; []
    Nyckelord :Growth hormone; insulin; SREBP-1; lipogenic enzymes; microsomal triglyceride transfer protein; PPARalpha; LXRalpha; triglycerides; liver;

    Sammanfattning : Growth hormone (GH) plays a key role in the regulation of lipid and lipoprotein metabolism. Its sexually dimorphic secretory pattern regulates many sex-differentiated functions in the liver, such as triglyceride synthesis and VLDL secretion. LÄS MER

  3. 2. Adipose tissue gene expression & candidate genes for obesity

    Författare :Lovisa Johansson; Diabetes - klinisk obesitasforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

    Sammanfattning : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. LÄS MER

  4. 3. Molecular mechanisms of antidiabetic effects of estrogen

    Författare :Galyna Bryzgalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen; glucose tolerance; insulin sensitivity; lipogenic genes; Lepr; Stat3; G6pc; Srebp1c;

    Sammanfattning : The role of estrogen in the development and regulation of female reproduction is well established. However, recent studies demonstrate that estrogen has a multiple effects on body functions. At present, it is becoming well recognized that one of the important roles of estrogen is the maintenance of glucose homeostasis. LÄS MER

  5. 4. Estrogen signaling in metabolic disease : a functional genomics approach

    Författare :Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Sammanfattning : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. LÄS MER

  7. 5. Molecular studies on sex differences in hepatic gene expression and fuel metabolism

    Författare :Louisa Cheung; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In nature, sex difference is a multifactorial phenomenon. Although having a genotype of XX or XY determines the sex of an individual, the phenotypic sex differences are orchestrated by multiple factors such as developmental stages, nutritional condition, endocrine status and environmental factors. LÄS MER