Sökning: "lipid-protein interaction"

Hittade 4 avhandlingar innehållade orden lipid-protein interaction.

  1. 1. Property-controlling Enzymes at the Membrane Interface

    Författare :Changrong Ge; Åke Wieslander; Marcelo E. Guerin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; monotopic membrane protein; lipid-protein interaction; membrane curvature; glycosyltransferase; Rossmann fold; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Monotopic proteins represent a specialized group of membrane proteins in that they are engaged in biochemical events taking place at the membrane interface. In particular, the monotopic lipid-synthesizing enzymes are able to synthesize amphiphilic lipid products by catalyzing two biochemically distinct molecules (substrates) at the membrane interface. LÄS MER

  3. 2. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Författare :Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Sammanfattning : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. LÄS MER

  4. 3. Modeling of voltage-gated ion channels

    Författare :Pär Bjelkmar; Erik Lindahl; Toby W. Allen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular modeling; Molecular dynamics; Voltage-gating; Ion channels; Protein structure prediction; Chemistry; Kemi; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Sammanfattning : The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by molecular modeling techniques. LÄS MER

  5. 4. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Författare :Irem Nasir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER