Sökning: "lipid signaling"

Visar resultat 21 - 25 av 195 avhandlingar innehållade orden lipid signaling.

  1. 21. Intricate aspects of the thioredoxin system in redox signaling

    Författare :Marcus Cebula; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all downstream events. These modifications can be reversed by redox catalysts of which the thioredoxin system forms one of the most prominent. LÄS MER

  3. 22. Rewiring ret : PTB-adaptor regulated signaling and cell biology

    Författare :T Kalle Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Ret receptor belongs to a group of transmembrane tyrosine kinase receptors that serve to transduce environmental signals into cellular responses. Upon extracellular ligand activation the receptors dimerize and their structural conformation is altered into one that allows for interaction with proteins in the cell cytosol. LÄS MER

  4. 23. Neuropeptides and GABA in control of insulin producing cells in Drosophila

    Författare :Jeannette Söderberg; Åsa Winther; Dick R. Nässel; Susan Broughton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; insulin signaling; metabolism; feeding; DTK; DSK; GABA; stress resistance; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : Insulin plays an important role in metabolic regulation as well as in growth, fecundity and stress resistance. In order to understand more about the regulation of insulin-like peptide (DILP) production and release we investigate the impact of neuropeptide (DTK) signaling and classical neurotransmitter (GABA) signaling onto the insulin producing cells of the Drosophila brain. LÄS MER

  5. 24. Roles of PI3-kinase and ARAP2 in regulating glucose metabolism

    Författare :Aditi Chaudhari; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PI3-kinase; Type 2 diabetes; ARAP2; Lipid droplets; metabolism;

    Sammanfattning : Insulin signaling is mediated by a complex, highly integrated network which functions to control multiple metabolic and growth processes throughout the organism. A key enzyme in the insulin signaling network is phosphatidylinositol 3-kinase (PI3-kinase). LÄS MER

  7. 25. Insulin signaling and glucose transport in insulin resistant human skeletal muscle

    Författare :Håkan K R Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; insulin resistance; type 2 diabetes; glucose transport; insulin signaling; first-degree relatives; AS160; SelS; rosiglitazone treatment;

    Sammanfattning : Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize the molecular mechanism of skeletal muscle insulin resistance in Type 2 diabetes. LÄS MER