Sökning: "lipid rafts"

Visar resultat 16 - 20 av 33 avhandlingar innehållade orden lipid rafts.

  1. 16. Applications of in situ proximity ligation assays for cancer research and diagnostics

    Författare :Liza Löf; Masood Kamali-Moghaddam; Ulf Landegren; J.Paul Robinson; Uppsala universitet; []
    Nyckelord :Cancer; Diagnostics; Research; Prognostics; Method development; Flow cytometry; Drug delivery; Molekylär medicin; Molecular Medicine;

    Sammanfattning : In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim. LÄS MER

  3. 17. GPCRs regulating catecholaminergic cell survival and function : focus on GPR37

    Författare :Ebba Gregorsson Lundius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysfunction and dysregulation of catecholaminergic signaling are major causes of many neurological and psychiatric disorders, including Parkinson’s disease (PD), schizophrenia, ADHD and drug addiction. Currently an incomplete understanding of the mechanisms regulating the function and survival of catecholaminergic neurons hinders the development of effective treatments. LÄS MER

  4. 18. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

  5. 19. Toxicity and biological impact of metal and metal oxide nanoparticles : Focus on the vascular toxicity of ultra-small titanium dioxide nanoparticles

    Författare :Narges Bayat; Susana Cristobal; Janeck James Scott-Fordsmand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nanoparticles; Nanotoxicology; Ultra-small nanoparticles; Biochemistry; biokemi;

    Sammanfattning : The application of nanoparticles (NPs) in different technologies has led to tremendous advancement in those fields.  Moreover, there is growing interest in application of ultra-small NPs (USNPs) at 1-3 nm due to their distinct molecule like features. Parallel to these promises, there is a growing concern regarding their safety. LÄS MER

  7. 20. The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins

    Författare :Ji-Yeun Hur; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the brain that eventually results in cognitive decline. Characteristic hallmarks of AD are senile plaques containing the amyloid beta-peptide (Abeta) and neurofibrillary tangles containing hyperphosphorylated tau protein. LÄS MER