Sökning: "linear mixed modeling"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden linear mixed modeling.

  1. 1. Mixed-Integer Optimization Modeling for the Simultaneous Scheduling of Component Replacement and Repair

    Författare :Gabrijela Obradovic; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mathematical Modeling; Workshop Scheduling; Maintenance Optimization; Simultaneous Scheduling; Mixed-Integer Linear Optimization; Multi-Objective Optimization; Contracting Forms;

    Sammanfattning : Maintenance is a critical aspect of many industries, playing an indispensable role in ensuring the optimal functionality, reliability, and longevity of various assets, equipment, and infrastructure. For a system to remain operational, maintenance of its components is required, and for the industry to optimize its operations, establishment of good maintenance policies and practices is vital. LÄS MER

  3. 2. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    Författare :Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). LÄS MER

  4. 3. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

    Författare :Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
    Nyckelord :pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. LÄS MER

  5. 4. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation

    Författare :Xia Shen; Örjan Carlborg; Lars Rönnegård; William Hill; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; statistical genetics; quantitative trait loci; genome-wide association study; genomic selection; genetic variance; hierarchical generalized linear model; linear mixed model; random effect; heteroscedastic effects model; variance-controlling genes; Complex Systems – Microdata Analysis;

    Sammanfattning : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. LÄS MER

  7. 5. Ghosts and machines : regularized variational methods for interactive simulations of multibodies with dry frictional contacts

    Författare :Claude Lacoursière; Bo Kåggström; Ander Klarbring; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Discrete mechanics; Variational method; Contact problems; Impacts; Least action principle; Saddle point problems; Lagrange Multipliers; Constrained systems; Multibody Systems; Numerical regularization; Constraint realization; Constraint stabilization; Dry friction; Differential Algebraic Equations; Nonsmooth problems; Linear Complementarity; Quaternion algebra; Numerical linear algebra; Physics modeling; Interactive simulation; Numerical stability; Rigid body dynamics; Dissipative systems; Computational physics; Beräkningsfysik;

    Sammanfattning : A time-discrete formulation of the variational principle of mechanics is used to provide a consistent theoretical framework for the construction and analysis of low order integration methods. These are applied to mechanical systems subject to mixed constraints and dry frictional contacts and impacts---machines. LÄS MER