Sökning: "ligandbinding domain"

Hittade 1 avhandling innehållade orden ligandbinding domain.

1. 1. Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene

   Författare :Maria Backlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AhR; omeprazole; primaquine; CYP1A1; ligand-independent activation; ligandbinding domain; protein tyrosine kinase; c-src kinase;

   Sammanfattning : The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that is responsible for the activation of several response genes, of which the best characterised is the CYP1A1 gene. The prototype high affinity ligand for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). LÄS MER