Sökning: "leukotriene"

Visar resultat 1 - 5 av 107 avhandlingar innehållade ordet leukotriene.

  1. 1. Leukotriene C4 synthase : studies on oligomerization and subcellular localization

    Författare :Jesper Svartz; Mats Söderström; Sven Hammarström; Colin Funk; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. LÄS MER

  3. 2. Leukotriene C synthase : an enzyme distinct from microsomal and cytosolic glutathione transferases

    Författare :Mats Söderström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1

    Författare :Alan Sabirsh; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; fluidity; redox; chemotaxis; luciferase; calcium; ligand binding; point mutation; modelling; antibody; BLT1; leukotriene; pharmacology; GPCR; G-protein; receptor;

    Sammanfattning : Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. LÄS MER

  5. 4. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Författare :Astrid Bengtsson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Sammanfattning : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. LÄS MER

  7. 5. Analysis of epithelial electrophysiological function in paediatric intestinal biopsies

    Författare :Annika Reims; Göteborgs universitet; []
    Nyckelord :Cystic fibrosis; CFTR; coeliac disease; Ussing chamber; intestinal permeability; ion transport; leukotriene; human; duodenum;

    Sammanfattning : Intestinal biopsies are routinely taken from children under investigation of failure to thrive, diarrhoea, abdominal pain and/or malnutrition. These biopsies are usually only evaluated morphologically, i.e. no information is collected with regard to mucosal function. LÄS MER