Sökning: "leukotriene receptor antagonist"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden leukotriene receptor antagonist.
1. Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1
Sammanfattning : Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. LÄS MER
2. Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium
Sammanfattning : The transformation of the unstable intermediate leukotriene (LT) A4 into the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal glutathione S-transferase type 2 (MGST2) and type 3 (MGST3). Together, these eicosanoids also known as cysteinyl leukotrienes (cys-LT) are key mediators of immediate hypersensitivity reactions. LÄS MER
3. Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
Sammanfattning : Infection and inflammation are characterized by the release of chemotactic substances that activate cells of the immune system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. LÄS MER
4. Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases
Sammanfattning : Leukotrienes (LTs) are a family of lipid mediators that are involved in host defense and inflammatory responses. They are synthesized from arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are divided into two classes, the classical chemoattractant leukotriene B4 (LTB4), and spasmogenic cysteinyl leukotrienes (cys-Us) including LTC4, LTD4 and LTE4. LÄS MER
5. Intrafollicular pressure and biochemical mediators in ovulation
Sammanfattning : Ovulation is the process whereby the preovulatory follicle ruptures to enable a fertilisable ovum to escape from the interior of the ovary to the oviduct. During the ovulatory process, from he onset of the preovulatory LH-surge to the follicular rupture, marked biochemical and structural changes in follicles to enable it to rupture. LÄS MER