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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Evolution and structure of leukotriene A4 hydrolase

    Författare :Filippa Kull; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) B4 is a potent leukocyte chemotactic and aggregating agent involved in a variety of inflammatory and allergic disorders. The enzyme leukotriene A4 hydrolase catalyzes the hydrolysis of LTA4 into this proinflammatory mediator, leukotriene B4. LÄS MER

  3. 2. Catalytic mechanisms and evolution of leukotriene A4 hydrolyse

    Författare :Fredrik Tholander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation is the first response of the body to infection or physical irritation. This response can potentially trigger the whole immune system but in the initial stage mainly involves leukocytes of the innate immune system and a complex cascade of chemical mediators, which by different means control, maintain and resolve the process. LÄS MER

  4. 3. Leukotriene A4 hydrolase : exploration of the active sites and catalytic mechanisms by site-directed mutagenesis

    Författare :Martina Blomster Andberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) A4 is a pivotal intermediate in the biosynthesis of leukotrienes, a family of potent lipid mediators involved in a variety of inflammatory and allergic disorders. The bifunctional zinc metalloenzyme LTA4 hydrolase converts LTA4 into LTB4, one of the most potent chemotaxins known to date. LÄS MER

  5. 4. Structural characterization of proteins to investigate their roles in diseases: Focus on MID & LTA4H

    Författare :Mahmudul Hasan; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Moraxella IgD binding protein; adhesin; leukotriene A4 hydrolase; small angle x-ray scattering; crystallography; circular dichroism;

    Sammanfattning : Protein molecules are responsible for many biological functions in cells. In order to fulfill their various biological roles, these chain-like molecules must fold into precise three-dimensional shapes. The knowledge of accurate molecular structures is a prerequisite for rational drug design and for structure based functional studies. LÄS MER

  7. 5. Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation

    Författare :Martin J Mueller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene (LT) A4 hydrolase catalyzes the committed step in the biosynthesis of LTB4, a classical chemoattractant and immuine-modulating lipid mediator involved in inflammation, host-defense against infections, and systemic, PAF-mediated, lethal shock. LTA4 hydrolase is a bifunctional zinc metalloenzyme with a chloride stimulated arginyl aminopeptidase activity. LÄS MER