Sökning: "leukemia"

Visar resultat 21 - 25 av 469 avhandlingar innehållade ordet leukemia.

1. 21. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells

   Författare :Veronika Viktorija Borutinskaite; Karl Eric Magnusson; Ruta Navakauskiene; Tor Olofsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leukemia; histone deacetylase inhibitors; retinoic acid; differentiation; apoptosis; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. LÄS MER

3. 22. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

   Författare :Charlotta Andersson; Eva Lundin; Aihong Li; Andreas Jonsson; Xingru Li; David M. Loeb; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

   Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. LÄS MER

4. 23. Chronic myeloid leukemia and cancer

   Författare :Niklas Gunnarsson; Anders Själander; Martin Höglund; Bertil Lindahl; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; Prevalence; Malignancies; Odds ratio; Standardized Incidence Ratio; Outcome; Autoimmune diseases; Survival; Epidemiology; epidemiologi; medicin; Medicine;

   Sammanfattning : Background Chronic myeloid leukemia (CML) is a relatively rare hematological malignancy with a constant incidence of approximately 90 new cases each year in Sweden (0.9 cases/100 000 inhabitants). The etiology is largely unknown but high doses of ionizing radiation are a known but rare risk factor. LÄS MER

5. 24. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia

   Författare :Maria Rodriguez Zabala; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; CRISPR screen; leukemia stem cell; cell surface receptor; metabolism; immunotherapy; CXCR4; GLUT1; TFR1; H2-K1;

   Sammanfattning : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. LÄS MER

7. 25. Leukemia Initiation in MLL-ENL Mediated Leukemogenesis

   Författare :Amol Ugale; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Luekemia; Cell of origin; Leukemia Initiation;

   Sammanfattning : In the blood system, knowledge on the regulation of hematopoietic stem cells (HSCs) and their immature progeny has provided roadmaps of differentiation. Such information can also have a value to understand the etiology of hematological cancers, since clinical heterogeneity and prognostic therapeutic outcomes have been proposed to associate with the specific developmental stage from which the transformed cells originate. LÄS MER