Sökning: "lethality"

Visar resultat 1 - 5 av 58 avhandlingar innehållade ordet lethality.

  1. 1. Factors modulating tRNA biogenesis and function in Saccharomyces cerevisiae

    Författare :Fu Xu; Anders Byström; Marcus J. O. Johansson; Raffael Schaffrath; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Translation; tRNA biogenesis; suppressor tRNA; Elongator complex; wobble uridine modifications; SUP4; YPK9; SSD1; serine tRNA; synthetic lethality; yeast; biology; biologi; molekylärbiologi; Molecular Biology; Genetics; genetik;

    Sammanfattning : Transfer RNA (tRNA) genes are transcribed by RNA polymerase III as precursors that undergo multiple processing steps to form mature tRNAs. These steps include processing of the 5’ leader and 3’ trailer sequences, addition of a 3’ CCA tail, removal of introns, and formation of modified nucleosides. LÄS MER

  3. 2. Nonionic surfactants : A multivariate study

    Författare :Lise-Lott Uppgård; Michael Sjöström; Svante Wold; Jiri Damborsky; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AEO; APG; aquatic toxicity; cellulose reactivity; Fock; MLR; multivariate data analysis; nonionic surfactant; PCA; physicochemical properties; PLS; QSAR; surface activity; viscose; Chemistry; Kemi;

    Sammanfattning : In this thesis technical nonionic surfactants are studied using multivariate techniques. The surfactants studied were alkyl ethoxylates (AEOs) and alkyl polyglucosides (APGs). The aquatic toxicity of the surfactants towards two organisms, a shrimp and a rotifer, was examined. The specified effect was lethality, LC50, as indicated by immobilisation. LÄS MER

  4. 3. Oocyte maturation in a contaminated environment : effects of perfluoroalkyl substances on bovine early embryo development in vitro

    Författare :Ida Hallberg; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The content of this thesis is dedicated to female fertility, and more specifically the maturing oocyte. The aim was to investigate chemicals present in the direct environment of the oocyte and more specifically to investigate the sensitivity of the oocyte to perfluoroalkyl substances (PFASs) using a bovine in vitro embryo production model. LÄS MER

  5. 4. Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells

    Författare :Nidal Ghosheh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human pluripotent stem cells; gene transcription; gene regulation; DNA methylation; transcriptome; hepatocytes;

    Sammanfattning : Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to recapitulate drug metabolism. LÄS MER

  7. 5. Wig-1 : a p53 target that regulates the mRNA of p53 and Myc – and more?

    Författare :Anna Vilborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Wig-1 is a transcriptional target of the tumor suppressor p53. p53 is activated by cellular stress and can induce a wide variety of responses. Some like apoptosis follow upon severe damage, while milder damage results in outcomes such as cell cycle arrest and DNA repair. Yet other p53 functions rely on physiological p53 levels. LÄS MER