Sökning: "leonard"

Visar resultat 6 - 10 av 68 avhandlingar innehållade ordet leonard.

  1. 6. The evaluation, preoperative and operative aspects of abdominal wall reconstruction for giant ventral hernia

    Författare :Leonard Clay; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND: The optimal method for surgical repair of giant ventral hernia remains to be determined. Different concepts for reinforcement have been used, which have decreased the risk for recurrence. LÄS MER

  3. 7. Growth factor pathways in human cancer : functional and therapeutic implications

    Författare :Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

    Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER

  4. 8. Studies on genetic and epigenetic regulation of gene expression dynamics

    Författare :Leonard Hartmanis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes cellular functional diversity and dysregulation of transcription is a central tenet of human disease. LÄS MER

  5. 9. Functional aspects of cellobiose dehydrogenase Applications for biosensor development

    Författare :Leonard Stoica; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Elektrokemi; Electrochemistry; Analytisk kemi; Analytical chemistry; bioelectrochemistry; direct electron transfer; lactose biosensor;

    Sammanfattning : Electrochemcial investigations were conducted for elucidating and understanding the relation between the various electron transfer processes occurring in cellobiose dehydrogenase (CDH) bound to an electrode surface. Substrate inhibition caused by cellobiose was proven to act in competition with the electron transfer to a two-electron acceptor and under a partial inhibition mechanism for the internal electron transfer process. LÄS MER

  7. 10. Optimizing thrombectomy and the patient in acute ischemic stroke

    Författare :Leonard Yeo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Endovascular stroke treatment offers acute stroke patient a high recanalization rate with a good chance of regaining independent functional outcomes. However up to half of such patients continue to have poor functional outcomes, and the aim of the project was to find ways to improve the rate of good outcomes. LÄS MER